ho·me·o·sta·sis n. The ability or tendency of an organism or cell to maintain internal equilibrium by adjusting its physiological processes
Diabetes is the leading cause of kidney failure, blindness in adults, and amputations. It is a major risk factor for heart disease, stroke, and birth defects, shortens average life expectancy by up to 15 years, and costs the nation in excess of $100 billion annually in health- related expenditures.
Over the next decade, these numbers will grow as the number of people afflicted by diabetes continues to increase at an accelerating rate.
At present, there is no method to prevent or cure diabetes, and available treatment have only limited success in controlling its devastating consequences.
The facts about diabetes leave no doubt about its seriousness. It is the seventh leading cause of death in the United States, currently; an estimated 18 million people in the U.S. have been diagnosed with diabetes – a six fold increase over the past four decades.
-Center for Disease Control-
Diabetes mellitus is a disorder of metabolism that results from a deficiency of insulin, a hormone secreted by the beta cells of the pancreas. Insulin is required for the removal of sugar (glucose) from the blood by muscles after a meal and to prevent the over secretion of glucose from the liver during periods of fasting
Insulin transports glucose into the cells for use as energy and storage as glycogen. It also stimulates protein synthesis and free fatty acid storage in the fat deposits. When a person lacks sufficient insulin, body tissues have less access to essential nutrients for fuel.
An inadequate amount or inefficient action of insulin leads to elevated blood levels of glucose, the hallmark of diabetes.
This problem is made more complex by the fact that diabetes mellitus is not a single disease, but occurs in several forms, and has complications that affect virtually every system of the body.
The most common forms are Type 1 (insulin- dependent) diabetes, which usually starts in childhood or adolescence, Type 1 diabetes is due to destruction of the beta cells of the pancreas by an autoimmune reaction (an attack on these cells by the body’s immune system that normally works to fend off infections).
Type 2 (non-insulin dependent) diabetes, which typically affects adults and increases dramatically with age and obesity. Type 2 diabetes results from a combination of chronic resistance to the biological action of insulin and the body’s inability of the pancreas to produce enough insulin to overcome the resistance
Other types include gestational diabetes mellitus (gdm), which occurs during pregnancy, and “other specific types” which include people who have diabetes because of a genetic defect, endocrinopathologies or exposure to certain drugs or chemicals.
Recent advances in the fields of molecular biology and neuro-endocrinology have revealed that insulin deficiency may be due to a breakdown in the communication and signaling mechanisms associated with the central nervous system and metabolism
“Disturbances in cell signaling are central to disturbances in insulin secretion and action, which lead to diabetes and to both micro- and macrovascular complications.”
–American Diabetes Association-
“Insulin receptors and insulin signaling proteins are widely distributed throughout the central nervous system. New evidence now indicates that insulin participates in the central nervous system control of food intake and body weight, and the stage is now set for studies to determine if impaired central nervous system signaling contributes to the pathogenesis of two common metabolic diseases, obesity and type-2 diabetes.”
Health care is slowly changing its focus from treatment of metabolic disorders with drugs and chemicals to shifting towards procedures that restore and maintain the normal communication and control systems of the human body.
Central Nervous System & Metabolism
The central nervous system is the master control system of the body and every single function reflects its activity. Nerve impulses travel from the brain, down the spinal cord and out through nerves to all parts of the body.
Nerve impulses then return to the brain through return pathways.
There are in excess of 100 billion neurons, or nerve cells in the human central nervous system and the number of possible interconnections between these cells is greater than the total number of atoms in the known universe.
Recent research has clearly shown that even activity that occurs at the cellular and molecular levels are controlled and coordinated by the central nervous system.
Metabolism: The sum of all physical and chemical changes that take place within an organism; all energy and material transformations that occur within living cells.
Tabers Medical Dictionary
The limbic system is the area of the brain that maintains homeostasis and the hypothalamus is perhaps the most important part of the limbic system. It is the “brain of the brain” and is without question the single most intricate and complicated part of the brain. The hypothalamus controls homeostasis in the brain by way of feedback loops. The combined neurological and endocrine function of the hypothalamus allows it to play a prominent role in the regulation of numerous bodily functions including the control of metabolism.
Factors such as blood sugar levels, temperature, fluid and electrolyte balance, blood pressure, and body-weight are held to a precise value called the set-point, and though it can migrate from day to day, it usually remains remarkably fixed
To achieve the task of maintaining metabolic balance, the hypothalamus must receive inputs about the state of the body, and must be able to initiate compensatory changes as needed.
The hypothalamus receives millions of nerve messages from complex areas of the rest of the nervous system including the nucleus of the solitary tract, reticular formation, the retinas, circumentular organs, the limbic and olfactory systems, sense organs, neocortex, osmoreceptors, as well as numerous touch receptors through the body.
This input into the hypothalamus allows it to regulate and integrate heart rate, blood pressure, respiratory rate, digestion, emotional responses, behavior, sex drive, body temperature, appetite, sleep cycles, blood sugar levels, metabolism, and much more.
When the hypothalamus senses any type of imbalance, it corrects it by one of two ways.
1. Sending nerve signals to the
autonomic nervous system.
2. Sending endocrine signals to the
The effectiveness of the hypothalamus to control metabolism and other functions is directly related to the functional capability of the nervous system to be able to send and receive nerve messages and especially to maintain the integrity of those nerve messages as they travel along the spinal cord.
Spinal Cord and Nerve Interference
The spinal cord is both a cable and a switchboard. As a cable, it connects the brain with the rest of the nerves in the body. As a switchboard, it coordinates muscle movements, reflexes and other activities under its direct control.
The spinal cord is a direct extension of the brain, composed of the same kind of nerve cells, fibers and supporting glial cells as those of the brain.
The spinal cord is composed of 24 individual vertebra, stacked on top of one another. The spine is straight when viewed from the front or the rear. When viewed from the side, it forms a series of geometric curves or arcs. This arrangement of spinal curves is much stronger than a more rigid straight column.
When the spine is in its optimal structural position, the nervous system pathways are protected, and the integrity of nerve impulses traveling to and from the brain at an optimum level. This is when the nervous system can best achieve homeostasis and maintains its metabolism.
Because the vertebrae are moveable, they are also susceptible to various stresses and forces, which can cause them to lose their proper position. This condition is called a vertebral subluxation.
Subluxations interfere with the normal flow of nerve impulses and can cause an increase or decrease of nerve activity. This is why metabolic disorders are often related to imbalances in the endocrine system.
Subluxations may be referred to in scientific literature by a variety of names including spinal lesions, nerve dysfunction, nerve impingement, double crush phenomena, neuritis, dysponesis, neuropathy, and many others.
Spinal nerve interference has been documented by leading scientific researchers to be a contributing factor of endocrine and metabolic disorders including diabetes.
“Research at the Still Institute showed that spinal lesions resulted in pathological changes in the blood, urine, and tissue fluids. Spinal lesions of the atlas & axis (C1 & C2) were associated with abnormal function of the pituitary gland, resulting in abnormal hormone secretions.”
–Still Research Institute-
“Hyper functional or Hypo functional neurons along a neural chain prevent normal nerve transmission causing disturbances in the homeostasis of the cells, tissue, and organs.”
Dr. T.N Lee, Academy of Pain Research
“Nerves branch at specific levels of the spinal column, thus dysfunction of visceral organs may be associated with spinal nerve dysfunction at certain branches or levels of the spine. Because of compensation, the primary level of spinal somatic dysfunction may be at a level different from the level of the nerve root innervating the dysfunctional organ or system.”
U.S. Medicare Policy
“A study of 46 insulin-dependent patients, who had had no indication of neurological pain, was compared with 46 age-matched control subjects. Spinal somatosensory evoked potentials were recorded from various segments of the spine. The study revealed that patients with juvenile diabetes without clinical evidence of neuropathy can have defects in spinal afferent transmission.”
Annuals of Neurology
“Oral glucose tolerance testing was performed in 201 subjects with spinal cord trauma. The dependent variables included the values from the oral glucose tolerance test, (glucose, insulin) and diagnostic classification (ie Diabetes Mellitus, impaired glucose tolerance. The total group consisted of 169 patients. The study concluded that patients with the greatest levels of neurological deficit have increased risk of developing disorders of metabolism.”